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General => Matemáticas => Mensaje iniciado por: lpjplulukuk en Mayo 09, 2013, 01:04:57 pm
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Regulatory interactions in the recognition of endocytic sorting signals
Recognition of tyrosine-based endocytic signals by AP-2 complexes is enhanced by clathrin coats and by 3'-phosphoinositides. Proposed models for the capture of membrane cargo receptors by clathrin-coated pits. (A) AP-2 complexes are first targeted from the cytosol to the plasma membrane by interaction with its putative membrane-bound docking complex where it interacts with cytosolic clathrin to form the lattice of coated pits (1). AP-2 complexes located in partially formed coated pits (2) have a clathrin-dependent increase in the affinity of the 2 chain for receptor tails. This leads to the capture of mobile receptors (3) into the coated pit (4). It is proposed that the linkage between clathrin binding to APs and their increased affinity for receptors ensures that coated pit assembly is coupled to receptor sorting. (B) AP-2 complexes targeted to the plasma membrane by its putative membrane-bound docking complex can interact with membrane-bound 3'-phosphoinositides (2) leading to an increase in the affinity of the 2 chain for the tyrosine-based endocytic signal located in the cytoplasmic tail of membrane receptors,microsoft office 2010 product key (http://www.office2007productkey.com). The AP complex (3) recruits cytosolic clathrin to form a coated pit or can be captured by available clathrin already located at the edge of a coated pit.